Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16852137 | 1.00 | KDM4E (0.53) | KDM4EALDH1A1KMT2AMEN1PIK3CD | |
| SCHEMBL6629070 | 1.00 | KDM4E (0.53) | KDM4EALDH1A1KMT2AMEN1PIK3CD | |
| SCHEMBL6629183 | 0.88 | PIK3CD (0.45) | KDM4EPIK3CD | |
| SCHEMBL15133968 | 0.88 | PIK3CD (0.45) | KDM4EPIK3CD | |
| SCHEMBL13923638 | 0.88 | PIK3CD (0.45) | KDM4EPIK3CD | |
| SCHEMBL358665 | 0.85 | KDM4E (0.50) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL358664 | 0.85 | KDM4E (0.50) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL3419549 | 0.84 | PIK3CD (0.41) | KDM4EALDH1A1KMT2AMEN1PIK3CD | |
| SCHEMBL12225611 | 0.82 | ALDH1A1 (0.45) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL13519611 | 0.82 | ALDH1A1 (0.45) | KDM4EALDH1A1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200407338-A1 | ISOQUINOLINE DERIVATIVES AND USE THEREOF | PURDUE PHARMA LP (US) | 2020-12-31 | — | — | US | disclosed |
| US-10738026-B2 | Isoquinoline derivatives and use thereof | PURDUE PHARMA L.P. (US) | 2020-08-11 | — | — | US | disclosed |
| US-10730866-B2 | Indole derivatives and use thereof | PURDUE PHARMA L.P. (US) | 2020-08-04 | — | — | US | disclosed |
| US-10005768-B2 | Carboxamide derivatives and use thereof | PURDUE PHARMA L.P. (US) | 2018-06-26 | — | — | US | disclosed |
| US-9695144-B2 | Dibenzazepine derivatives and use thereof | PURDUE PHARMA L.P. (US) | 2017-07-04 | — | — | US | disclosed |
| US-20170096421-A1 | Carboxamide Derivatives and Use Thereof | PURDUE PHARMA L.P. | 2017-04-06 | — | — | US | disclosed |
| US-20170057942-A1 | ISOQUINOLINE DERIVATIVES AND USE THEREOF | PURDUE PHARMA L.P. | 2017-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10738026-B2 | Isoquinoline derivatives and use thereof | KCNQ3, KCNQ5, KCNQ4 | KDM4E 1788/4885ALDH1A1 550/4885KMT2A 1856/4885 |
| US-20170057942-A1 | ISOQUINOLINE DERIVATIVES AND USE THEREOF | KCNQ3, KCNQ5, KCNQ4 | KDM4E 1788/4885ALDH1A1 550/4885KMT2A 1856/4885 |
| US-10005768-B2 | Carboxamide derivatives and use thereof | TRPV1, CACNA1A, SCN10A | KDM4E 1185/4885ALDH1A1 1621/4885KMT2A 1142/4885 |
| US-20200407338-A1 | ISOQUINOLINE DERIVATIVES AND USE THEREOF | KCNQ3, KCNQ5, KCNQ4 | KDM4E 1788/4885ALDH1A1 550/4885KMT2A 1856/4885 |
| US-20170096421-A1 | Carboxamide Derivatives and Use Thereof | TRPV1, CACNA1A, SCN10A | KDM4E 1185/4885ALDH1A1 1621/4885KMT2A 1142/4885 |
| US-10730866-B2 | Indole derivatives and use thereof | TRPC4, TRPV4, TRPV1 | KDM4E 206/4885ALDH1A1 1024/4885KMT2A 1731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.