Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19347397 | 0.81 | KDM4E (0.67) | KDM4ELMNAALOX15TSHRACMSD | |
| SCHEMBL22455532 | 0.80 | KDM4E (0.64) | KDM4ELMNAALOX15TSHRACMSD | |
| SCHEMBL18167973 | 0.79 | KDM4E (0.58) | KDM4ELMNAALOX15TSHRACMSD | |
| SCHEMBL16834707 | 0.77 | KDM4E (0.57) | KDM4ELMNAALOX15TSHRACMSD | |
| SCHEMBL31431975 | 0.77 | KDM4E (0.55) | KDM4ELMNAALOX15TSHRACMSD | |
| SCHEMBL2639071 | 0.77 | KDM4E (0.56) | KDM4ELMNAALOX15TSHRACMSD | |
| SCHEMBL18167999 | 0.76 | KDM4E (0.55) | KDM4ELMNAALOX15TSHRACMSD | |
| SCHEMBL3117402 | 0.75 | KDM4E (0.68) | KDM4ELMNAALOX15TSHRACMSD | |
| SCHEMBL30951916 | 0.75 | KDM4E (0.68) | KDM4ELMNAALOX15TSHRACMSD | |
| SCHEMBL18575633 | 0.75 | KDM4E (0.68) | KDM4ELMNAALOX15TSHRACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-B1 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS INC (US) | 2017-03-08 | — | — | EP | disclosed |