Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | ECE1 | P42892 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18167973 | 0.86 | KDM4E (0.58) | KDM4ELMNAALOX15TSHRACMSD | |
| SCHEMBL15650342 | 0.84 | KCNH2 (0.49) | KDM4ELMNAKCNH2CACNA1CSCN5A | |
| SCHEMBL18167999 | 0.83 | KDM4E (0.55) | KDM4ELMNAALOX15TSHRACMSD | |
| SCHEMBL1040553 | 0.83 | GRM5 (0.49) | KDM4ELMNAKCNH2CACNA1CSCN5A | |
| SCHEMBL16834707 | 0.81 | KDM4E (0.57) | KDM4ELMNAALOX15TSHRACMSD | |
| SCHEMBL18575634 | 0.81 | KDM4E (0.57) | KDM4ELMNAALOX15TSHRACMSD | |
| SCHEMBL2639071 | 0.81 | KDM4E (0.56) | KDM4ELMNAALOX15TSHRACMSD | |
| SCHEMBL2251120 | 0.80 | KDM4E (1.00) | KDM4ELMNAALOX15TSHRACMSD | |
| SCHEMBL29484609 | 0.80 | KDM4E (1.00) | KDM4ELMNAALOX15TSHRACMSD | |
| SCHEMBL3117402 | 0.79 | KDM4E (0.68) | KDM4ELMNAALOX15TSHRACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021216812-A1 | GALACTOKINASE INHIBITORS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2021-10-28 | — | — | WO | disclosed |
| WO-2017153527-A1 | NOVEL INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE GAMMA | ASTRAZENECA AB (SE) | 2017-09-14 | — | — | WO | disclosed |
| CN-1332942-C | Sulfonylamino-acetic acid derivatives and their use as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD (CH) | 2007-08-22 | — | — | CN | disclosed |
| CN-1703397-A | Sulfonylamino-acetic acid derivatives and their use as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD (CH) | 2005-11-30 | — | — | CN | disclosed |