Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 5/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 7/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 2/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2808456 | 0.88 | CNR1 (0.37) | CD38BDKRB1CNR1PTGS2CNR2 | |
| SCHEMBL14856605 | 0.88 | FAAH (0.35) | BDKRB1CNR1PTGS2FAAHTRPV1 | |
| SCHEMBL185944 | 0.85 | FAAH (0.36) | BDKRB1CNR1PTGS2FAAHTRPV1 | |
| SCHEMBL14856851 | 0.85 | FAAH (0.34) | BDKRB1CNR1PTGS2FAAHTRPV1 | |
| SCHEMBL14856819 | 0.85 | BDKRB1 (0.33) | BDKRB1CNR1PTGS2FAAHTRPV1 | |
| SCHEMBL196899 | 0.85 | BDKRB1 (0.33) | BDKRB1CNR1PTGS2FAAHTRPV1 | |
| SCHEMBL2807818 | 0.85 | PTGS2 (0.39) | BDKRB1CNR1PTGS2CNR2JAK1 | |
| SCHEMBL14856558 | 0.84 | BDKRB1 (0.36) | BDKRB1CNR1FAAHTRPV1 | |
| SCHEMBL14856726 | 0.84 | FAAH (0.35) | BDKRB1CNR1PTGS2FAAHTRPV1 | |
| SCHEMBL2806879 | 0.82 | BDKRB1 (0.41) | BDKRB1CNR1PTGS2CNR2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |