Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.62 |
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.56 |
| ▸ | KDM4A | O75164 | 1/20 | 0.56 |
| ▸ | KDM5A | P29375 | 4/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16034316 | 0.78 | KDM5A (0.57) | KDM2BKDM4CKDM4AKDM5AKDM5B | |
| SCHEMBL7101565 | 0.78 | KDM4E (0.47) | KDM2BKDM4CKDM4AKDM5AKDM5B | |
| SCHEMBL16034388 | 0.78 | KDM2B (0.60) | KDM2BKDM4CKDM4AKDM5AKDM5B | |
| SCHEMBL17710639 | 0.78 | HRH3 (0.44) | KDM2BKDM4CKDM4AKDM5AKDM5B | |
| SCHEMBL16033424 | 0.77 | KDM2B (1.00) | KDM2BKDM4CKDM4AKDM5AKDM5B | |
| SCHEMBL17710633 | 0.77 | HRH3 (0.43) | KDM2BKDM4CKDM4AKDM5AKDM5B | |
| SCHEMBL17710631 | 0.77 | HRH3 (0.43) | KDM2BKDM4CKDM4AKDM5AKDM5B | |
| SCHEMBL17710640 | 0.76 | SCD5 (0.43) | KDM2BKDM4CKDM4AKDM5AKDM5B | |
| SCHEMBL17710626 | 0.76 | SCD5 (0.43) | KDM2BKDM4CKDM4AKDM5AKDM5B | |
| SCHEMBL18579661 | 0.75 | KDM5A (0.60) | KDM2BKDM4CKDM4AKDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963441-B2 | Histone demethylase inhibitors | CELGENE QUANTICEL RESEARCH, INC. (US) | 2018-05-08 | — | — | US | disclosed |
| US-20170066739-A1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE PHARMACEUTICALS INC (US) | 2017-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170066739-A1 | HISTONE DEMETHYLASE INHIBITORS | KDM1B, KDM1A, KDM3B | KDM2B 19/4885KDM4C 13/4885KDM4A 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.