Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4016775 | 0.77 | SMN1; SMN2 (0.32) | SMN1; SMN2 | |
| SCHEMBL688697 | 0.75 | SMN1; SMN2 (0.38) | SMN1; SMN2 | |
| SCHEMBL7261140 | 0.75 | POLB (0.31) | SMN1; SMN2 | |
| SCHEMBL3905171 | 0.75 | SMN1; SMN2 (0.38) | SMN1; SMN2 | |
| SCHEMBL688825 | 0.75 | SMN1; SMN2 (0.38) | SMN1; SMN2 | |
| SCHEMBL1856194 | 0.75 | SMN1; SMN2 (0.35) | SMN1; SMN2 | |
| SCHEMBL4303583 | 0.73 | CYP2D6 (0.32) | SMN1; SMN2 | |
| SCHEMBL8516214 | 0.73 | CYP2D6 (0.32) | SMN1; SMN2 | |
| SCHEMBL14911103 | 0.72 | — | — | |
| SCHEMBL6206281 | 0.72 | CHRM2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863475-B1 | NOVEL THIOPHENE DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE-1 RECEPTOR AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-09-07 | — | — | EP | claimed |
| EP-1863787-B1 | HYDOGRENATED BENZO[C]THIOPHENE DERIVATIVES AS IMMUNOMODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-05-25 | — | — | EP | claimed |
| EP-1863474-B1 | NOVEL THIOPHENE DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE-1 RECEPTOR AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-11-12 | — | — | EP | claimed |