Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25440282 | 0.94 | HSD11B1 (0.31) | HTT | |
| SCHEMBL688697 | 0.77 | SMN1; SMN2 (0.38) | SMN1; SMN2CYP2D6HTT | |
| SCHEMBL1857962 | 0.77 | SMN1; SMN2 (0.31) | SMN1; SMN2 | |
| SCHEMBL688825 | 0.77 | SMN1; SMN2 (0.38) | SMN1; SMN2CYP2D6HTT | |
| SCHEMBL7261140 | 0.77 | POLB (0.31) | SMN1; SMN2 | |
| SCHEMBL3905171 | 0.77 | SMN1; SMN2 (0.38) | SMN1; SMN2CYP2D6HTT | |
| SCHEMBL112693 | 0.75 | ATM (0.32) | — | |
| SCHEMBL28340935 | 0.75 | ALDH1A1 (0.33) | — | |
| SCHEMBL4303583 | 0.75 | CYP2D6 (0.32) | SMN1; SMN2CYP2D6HTT | |
| SCHEMBL8516214 | 0.75 | CYP2D6 (0.32) | SMN1; SMN2CYP2D6HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0854140-B1 | Vitronectin receptor antagonists, their production and their use | SANOFI AVENTIS DEUTSCHLAND (DE) | 2013-11-06 | — | — | EP | disclosed |
| EP-0903353-B1 | Imidazolidine derivates, their preparation and use, and pharmaceutical compositions containing them | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-11-25 | — | — | EP | disclosed |
| EP-0820988-B1 | Imino derivatives as bone resorption inhibitors and vitronectin receptor antagonists | HOECHST AG (DE) | 2009-07-01 | — | — | EP | disclosed |
| EP-0842944-B1 | Heterocycles as inhibitors of leukocyte adhesion and as antagonists of VLA-4 | HOECHST AG (DE) | 2003-07-09 | — | — | EP | disclosed |
| EP-0918059-B1 | Substituted imidazoline derivatives, their preparation, their use, and pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| EP-0842943-B1 | 5-Ring heterocycles as inhibitors of leukocyte adhesion and as VLA-4 antagonists | HOECHST AG (DE) | 2003-02-26 | — | — | EP | disclosed |
| EP-0842945-B1 | Heterocycles as inhibitors of leukocyte adhesion and as antagonists of VLA-4 | HOECHST AG (DE) | 2003-02-19 | — | — | EP | disclosed |
| EP-0739898-B1 | Phosphonomonoester nucleic acids, methods for their preparation and their use | AVENTIS PHARMA GMBH (DE) | 2001-09-26 | — | — | EP | disclosed |
| EP-1077994-A1 | IMIDAZOLIDINE DERIVATIVES, THE PRODUCTION THEREOF, THEIR USE AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | Aventis Pharma Deutschland GmbH (DE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999060015-A1 | IMIDAZOLIDINE DERIVATIVES, THE PRODUCTION THEREOF, THEIR USE AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-11-25 | — | — | WO | disclosed |
| EP-0820988-A2 | Imino derivatives as bone resorption inhibitors and vitronectin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-01-28 | — | — | EP | disclosed |
| EP-0796855-A1 | Inhibitors of bone resorption and vitronectin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-09-24 | — | — | EP | disclosed |
| EP-0739898-A2 | Phosphonomonoester nucleic acids, methods for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-10-30 | — | — | EP | disclosed |
| EP-0729460-A1 | SUBSTITUTED 5-RING HETEROCYCLES, THEIR PREPARATION AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-09-04 | — | — | EP | disclosed |
| EP-0689549-A1 | NEW UREA DERIVATES, THEIR PREPARATION AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-01-03 | — | — | EP | disclosed |
| EP-0688315-A1 | NEW HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-12-27 | — | — | EP | disclosed |
| WO-1995014008-A1 | SUBSTITUTED 5-RING HETEROCYCLES, THEIR PREPARATION AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-05-26 | — | — | WO | disclosed |
| WO-1994022907-A1 | NEW UREA DERIVATES, THEIR PREPARATION AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-10-13 | — | — | WO | disclosed |
| WO-1994021607-A1 | NEW HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-09-29 | — | — | WO | disclosed |
| EP-0564972-A2 | Peptides with N-terminal modifications having bradykinin antagonistic activity | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-10-13 | — | — | EP | disclosed |