Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.37 |
| ▸ | CHRNA5 | P30532 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.35 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688825 | 1.00 | SMN1; SMN2 (0.38) | SMN1; SMN2CHRNB2CHRNA7CHRNA4CHRNA5 | |
| SCHEMBL3905171 | 1.00 | SMN1; SMN2 (0.38) | SMN1; SMN2CHRNB2CHRNA7CHRNA4CHRNA5 | |
| SCHEMBL17629524 | 0.94 | CHRNB2 (0.33) | SMN1; SMN2CHRNB2CHRNA7CHRNA4CHRNA5 | |
| SCHEMBL2788345 | 0.94 | CHRNB2 (0.33) | SMN1; SMN2CHRNB2CHRNA7CHRNA4CHRNA5 | |
| SCHEMBL688928 | 0.87 | — | — | |
| SCHEMBL8704065 | 0.82 | SMN1; SMN2 (0.37) | SMN1; SMN2CHRNB2CHRNA7CHRNA4CHRNA5 | |
| Hydrochloric Acid SCHEMBL21801417 | 0.82 | SMN1; SMN2 (0.40) | SMN1; SMN2CYP2D6POLB | |
| SCHEMBL8682105 | 0.79 | CHRM1 (0.44) | SMN1; SMN2CHRNB2CHRNA7CHRNA4CHRNA5 | |
| SCHEMBL8683160 | 0.79 | SMN1; SMN2 (0.35) | SMN1; SMN2CHRNB2CHRNA7CHRNA4CHRNA5 | |
| SCHEMBL6695503 | 0.78 | CHRM2 (0.39) | CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | disclosed |
| EP-2323980-A1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | Boehringer Ingelheim International GmbH (DE) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010026096-A1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-11 | — | — | WO | disclosed |