Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.35 |
| ▸ | FAAH | O00519 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185880 | 0.90 | BDKRB1 (0.47) | BDKRB1MEN1KMT2ATDP1TRPV1 | |
| SCHEMBL187120 | 0.89 | BDKRB1 (0.50) | BDKRB1TRPV1FAAH | |
| SCHEMBL2805998 | 0.88 | BDKRB1 (0.57) | BDKRB1MEN1KMT2ATDP1CNR1 | |
| SCHEMBL185085 | 0.84 | BDKRB1 (0.47) | BDKRB1MEN1KMT2ATRPV1FAAH | |
| SCHEMBL185457 | 0.81 | BDKRB1 (0.49) | BDKRB1TRPV1FAAH | |
| SCHEMBL185374 | 0.81 | MEN1 (0.47) | BDKRB1MEN1KMT2ATDP1TRPV1 | |
| SCHEMBL184989 | 0.78 | BDKRB1 (0.50) | BDKRB1TRPV1FAAH | |
| SCHEMBL2810040 | 0.78 | BDKRB1 (0.58) | BDKRB1MEN1KMT2AALDH1A1CNR1 | |
| SCHEMBL185745 | 0.78 | BDKRB1 (0.43) | BDKRB1MEN1KMT2ATDP1TRPV1 | |
| SCHEMBL2806049 | 0.76 | BDKRB1 (0.62) | BDKRB1ALDH1A1SMN1; SMN2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |