Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | PPIB | P23284 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187120 | 0.91 | BDKRB1 (0.50) | BDKRB1TRPV1PPIBFAAHRAB9A | |
| SCHEMBL2806959 | 0.89 | BDKRB1 (0.59) | BDKRB1ALDH1A1SMN1; SMN2PPIBRAB9A | |
| SCHEMBL14856425 | 0.88 | BDKRB1 (0.48) | BDKRB1ALDH1A1SMN1; SMN2TRPV1FAAH | |
| SCHEMBL185880 | 0.85 | BDKRB1 (0.47) | BDKRB1TRPV1FAAHRAB9ACYP3A4 | |
| SCHEMBL185841 | 0.84 | BDKRB1 (0.46) | BDKRB1ALDH1A1SMN1; SMN2TRPV1FAAH | |
| SCHEMBL185457 | 0.82 | BDKRB1 (0.49) | BDKRB1TRPV1FAAHRAB9ANPC1 | |
| SCHEMBL754425 | 0.81 | PPARD (0.44) | BDKRB1ALDH1A1SMN1; SMN2TRPV1FAAH | |
| SCHEMBL13128621 | 0.79 | BDKRB1 (0.53) | BDKRB1ALDH1A1SMN1; SMN2PPIBRAB9A | |
| SCHEMBL765812 | 0.79 | BDKRB1 (0.63) | BDKRB1ALDH1A1SMN1; SMN2RAB9ACYP1A2 | |
| SCHEMBL756449 | 0.78 | BDKRB1 (0.46) | BDKRB1ALDH1A1SMN1; SMN2FAAHCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |