Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | DAO | P14920 | 5/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | PIEZO1 | Q92508 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 2/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CYBB | P04839 | 1/20 | 0.31 |
| ▸ | NOX3 | Q9HBY0 | 1/20 | 0.31 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.31 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.31 |
| ▸ | THRA | P10827 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408206 | 0.83 | CES2 (0.37) | IDO1DAOTAS2R14PIEZO1MAPT | |
| SCHEMBL8226170 | 0.81 | IDO1 (0.54) | IDO1DAOTAAR1 | |
| SCHEMBL14082696 | 0.81 | CES2 (0.43) | IDO1DAOPIEZO1CES2 | |
| SCHEMBL8226773 | 0.80 | DAO (0.40) | IDO1DAOTAS2R14MAPTTAAR1 | |
| SCHEMBL23886964 | 0.80 | MEN1 (0.46) | IDO1MAPTCES2THRATHRB | |
| SCHEMBL18586260 | 0.79 | IDO1 (0.39) | IDO1DAOTAS2R14PIEZO1MAPT | |
| SCHEMBL27705804 | 0.79 | PTPN1 (0.39) | IDO1DAOTAS2R14PIEZO1MAPT | |
| SCHEMBL585296 | 0.78 | IDO1 (0.54) | IDO1DAOTAAR1 | |
| SCHEMBL23887333 | 0.78 | CYP2C9 (0.39) | IDO1MAPTCES2 | |
| SCHEMBL3410622 | 0.77 | IDO1 (0.42) | IDO1DAOTAS2R14PIEZO1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10239869-B2 | Sulfonamide compounds as voltage-gated sodium channel modulators | LUPIN LIMITED (IN) | 2019-03-26 | — | — | US | disclosed |
| CN-108349957-A | Sulfonamide compounds as modulators of voltage-gated sodium channels | 鲁平有限公司 | 2018-07-31 | — | — | CN | disclosed |
| EP-3344621-A1 | SULFONAMIDE COMPOUNDS AS VOLTAGE-GATED SODIUM CHANNEL MODULATORS | Lupin Limited (IN) | 2018-07-11 | — | — | EP | disclosed |
| US-20180186777-A1 | SULFONAMIDE COMPOUNDS AS VOLTAGE-GATED SODIUM CHANNEL MODULATORS | LUPIN LIMITED (IN) | 2018-07-05 | — | — | US | disclosed |
| WO-2017037682-A1 | SULFONAMIDE COMPOUNDS AS VOLTAGE-GATED SODIUM CHANNEL MODULATORS | LUPIN LIMITED (IN) | 2017-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10239869-B2 | Sulfonamide compounds as voltage-gated sodium channel modulators | SCN7A, SCN1A, SCN5A | IDO1 3662/4885DAO 4247/4885TAS2R14 571/4885 |
| US-20180186777-A1 | SULFONAMIDE COMPOUNDS AS VOLTAGE-GATED SODIUM CHANNEL MODULATORS | SCN7A, SCN1A, SCN5A | IDO1 3662/4885DAO 4247/4885TAS2R14 571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.