Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.42 |
| ▸ | BDKRB1 | P46663 | 9/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185850 | 0.93 | FAAH (0.38) | FAAHTRPV1BDKRB1CNR1NTRK1 | |
| SCHEMBL14856503 | 0.92 | FAAH (0.39) | FAAHTRPV1BDKRB1CNR1NTRK1 | |
| SCHEMBL2805174 | 0.88 | BDKRB1 (0.41) | BDKRB1CNR1NTRK1HPGDP2RX7 | |
| SCHEMBL14856700 | 0.85 | FAAH (0.38) | FAAHTRPV1BDKRB1NTRK1HPGD | |
| SCHEMBL185968 | 0.85 | OPRL1 (0.36) | FAAHTRPV1BDKRB1CNR1NTRK1 | |
| SCHEMBL187047 | 0.84 | BDKRB1 (0.37) | FAAHTRPV1BDKRB1CNR1NTRK1 | |
| SCHEMBL14856754 | 0.84 | TRPV1 (0.38) | FAAHTRPV1BDKRB1NTRK1HPGD | |
| SCHEMBL185703 | 0.81 | FAAH (0.37) | FAAHTRPV1BDKRB1HPGD | |
| SCHEMBL185740 | 0.81 | FAAH (0.35) | FAAHTRPV1BDKRB1CNR1NTRK1 | |
| SCHEMBL2811762 | 0.81 | BDKRB1 (0.35) | BDKRB1CNR1NTRK1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |