Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORA | P35398 | 2/20 | 0.82 |
| ▸ | RORC | P51449 | 1/20 | 0.82 |
| ▸ | RORB | Q92753 | 1/20 | 0.82 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.48 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2489597 | 0.90 | RORA (1.00) | RORARORCRORBPIK3CDPIK3CG | |
| SCHEMBL2959779 | 0.81 | RORA (0.69) | RORARORCRORBPIK3CDPIK3CG | |
| SCHEMBL19556832 | 0.79 | RORC (0.80) | RORARORCRORBSMN1; SMN2 | |
| SCHEMBL19556830 | 0.75 | RORC (0.74) | RORARORCRORBSMN1; SMN2 | |
| SCHEMBL3556136 | 0.74 | RORA (0.60) | RORARORCRORBPIK3CDPIK3CG | |
| SCHEMBL1487088 | 0.72 | RORA (0.54) | RORARORCRORBPIK3CDPIK3CG | |
| SCHEMBL12334613 | 0.72 | RORA (0.50) | RORARORCRORBIDH1HSD11B1 | |
| SCHEMBL12334055 | 0.72 | MCL1 (0.61) | RORARORCRORBIDH1HSD11B1 | |
| SCHEMBL21047664 | 0.72 | SMN1; SMN2 (0.72) | HSD11B1SMN1; SMN2KDM4EMEN1ALDH1A1 | |
| SCHEMBL12334606 | 0.71 | RORA (0.51) | RORARORCRORBHSD11B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586928-B2 | Modulators of the nuclear hormone receptor ROR | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-03-07 | — | — | US | disclosed |