Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 14/20 | 0.38 |
| ▸ | JAK2 | O60674 | 13/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28550699 | 1.00 | NTRK1 (0.38) | NTRK1JAK2RIPK1TLR7 | |
| SCHEMBL18555647 | 0.82 | RIPK1 (0.39) | NTRK1JAK2RIPK1 | |
| SCHEMBL18555600 | 0.82 | RIPK1 (0.39) | NTRK1JAK2RIPK1 | |
| SCHEMBL433008 | 0.82 | RIPK1 (0.52) | NTRK1JAK2RIPK1 | |
| SCHEMBL445614 | 0.82 | RIPK1 (0.52) | NTRK1JAK2RIPK1 | |
| SCHEMBL18878228 | 0.82 | RIPK1 (0.49) | NTRK1JAK2RIPK1 | |
| SCHEMBL18606763 | 0.82 | RIPK1 (0.49) | NTRK1JAK2RIPK1 | |
| SCHEMBL18588934 | 0.80 | CYP1A2 (0.41) | NTRK1JAK2RIPK1 | |
| SCHEMBL18588941 | 0.80 | NTRK1 (0.38) | NTRK1JAK2 | |
| SCHEMBL18588903 | 0.80 | NTRK1 (0.38) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11059827-B2 | Compounds and compositions useful for treating disorders related to NTRK | BLUEPRINT MEDICINES CORPORATION (US) | 2021-07-13 | — | — | US | disclosed |
| CN-108137607-B | Compounds and compositions suitable for treating NTRK-related disorders | 缆图药品公司 | 2021-04-06 | — | — | CN | disclosed |
| US-10370379-B2 | Compounds and compositions useful for treating disorders related to NTRK | BLUEPRINT MEDICINES CORPORATION (US) | 2019-08-06 | — | — | US | disclosed |
| US-10017512-B2 | Compounds and compositions useful for treating disorders related to NTRK | BLUEPRINT MEDICINES CORPORATION (US) | 2018-07-10 | — | — | US | disclosed |
| US-10017512-B2 | Compounds and compositions useful for treating disorders related to NTRK | BLUEPRINT MEDICINES CORPORATION (US) | 2018-07-10 | — | — | US | disclosed |
| US-20170145018-A1 | COMPOUNDS AND COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO NTRK | BLUEPRINT MEDICINES CORPORATION | 2017-05-25 | — | — | US | disclosed |
| US-20170145018-A1 | COMPOUNDS AND COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO NTRK | BLUEPRINT MEDICINES CORPORATION | 2017-05-25 | — | — | US | disclosed |
| US-20170066773-A1 | COMPOUNDS AND COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO NTRK | BLUEPRINT MEDICINES CORPORATION | 2017-03-09 | — | — | US | disclosed |
| US-20170066773-A1 | COMPOUNDS AND COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO NTRK | BLUEPRINT MEDICINES CORPORATION | 2017-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170066773-A1 | COMPOUNDS AND COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO NTRK | NTRK2, NTRK3, NTRK1 | NTRK1 3/4885JAK2 3027/4885RIPK1 793/4885 |
| US-10017512-B2 | Compounds and compositions useful for treating disorders related to NTRK | NTRK3, NTRK2, NTRK1 | NTRK1 3/4885JAK2 2715/4885RIPK1 1538/4885 |
| US-11059827-B2 | Compounds and compositions useful for treating disorders related to NTRK | NTRK2, NTRK3, NTRK1 | NTRK1 3/4885JAK2 3027/4885RIPK1 793/4885 |
| US-10370379-B2 | Compounds and compositions useful for treating disorders related to NTRK | NTRK3, NTRK2, NTRK1 | NTRK1 3/4885JAK2 2669/4885RIPK1 1468/4885 |
| US-20170145018-A1 | COMPOUNDS AND COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO NTRK | NTRK2, NTRK3, NTRK1 | NTRK1 3/4885JAK2 3027/4885RIPK1 793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.