Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 14/20 | 0.38 |
| ▸ | JAK2 | O60674 | 13/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18588908 | 1.00 | NTRK1 (0.38) | NTRK1JAK2RIPK1TLR7 | |
| SCHEMBL18555647 | 0.82 | RIPK1 (0.39) | NTRK1JAK2RIPK1 | |
| SCHEMBL18555600 | 0.82 | RIPK1 (0.39) | NTRK1JAK2RIPK1 | |
| SCHEMBL433008 | 0.82 | RIPK1 (0.52) | NTRK1JAK2RIPK1 | |
| SCHEMBL445614 | 0.82 | RIPK1 (0.52) | NTRK1JAK2RIPK1 | |
| SCHEMBL18878228 | 0.82 | RIPK1 (0.49) | NTRK1JAK2RIPK1 | |
| SCHEMBL18606763 | 0.82 | RIPK1 (0.49) | NTRK1JAK2RIPK1 | |
| SCHEMBL18588934 | 0.80 | CYP1A2 (0.41) | NTRK1JAK2RIPK1 | |
| SCHEMBL18588941 | 0.80 | NTRK1 (0.38) | NTRK1JAK2 | |
| SCHEMBL18588903 | 0.80 | NTRK1 (0.38) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137607-B | Compounds and compositions suitable for treating NTRK-related disorders | 缆图药品公司 | 2021-04-06 | — | — | CN | disclosed |