Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 7/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18581227 | 0.91 | THRB (0.48) | ALDH1A1SMN1; SMN2TSHRMAPK1NPSR1 | |
| SCHEMBL18593269 | 0.89 | TSHR (0.60) | ALDH1A1SMN1; SMN2TSHRMAPK1NPSR1 | |
| SCHEMBL18593273 | 0.89 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2TSHRMAPK1NPSR1 | |
| SCHEMBL18593272 | 0.87 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2TSHRMAPK1NPSR1 | |
| SCHEMBL20580645 | 0.82 | THRB (0.47) | ALDH1A1SMN1; SMN2TSHRMAPK1NPSR1 | |
| SCHEMBL18593270 | 0.82 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2TSHRMAPK1NPSR1 | |
| SCHEMBL18581098 | 0.82 | HDAC6 (0.49) | ALDH1A1SMN1; SMN2TSHRTHRB | |
| SCHEMBL18581129 | 0.80 | THRB (0.47) | ALDH1A1SMN1; SMN2TSHRMAPK1NPSR1 | |
| SCHEMBL18581793 | 0.80 | THRB (0.59) | ALDH1A1SMN1; SMN2TSHRMAPK1NPSR1 | |
| SCHEMBL18581864 | 0.80 | TP53 (0.47) | ALDH1A1SMN1; SMN2TSHRCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10029995-B2 | [6,6] fused bicyclic HDAC8 inhibitors | FORMA THERAPEUTICS, INC. (US) | 2018-07-24 | — | — | US | disclosed |
| US-20170066729-A1 | [6,6] FUSED BICYCLIC HDAC8 INHIBITORS | Valo Health, LLC | 2017-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170066729-A1 | [6,6] FUSED BICYCLIC HDAC8 INHIBITORS | HDAC8, HDAC3, HDAC2 | ALDH1A1 1338/4885SMN1; SMN2 3209/4885TSHR 2168/4885 |
| US-10029995-B2 | [6,6] fused bicyclic HDAC8 inhibitors | HDAC8, HDAC3, HDAC2 | ALDH1A1 1338/4885SMN1; SMN2 3209/4885TSHR 2168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.