Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.41 |
| ▸ | CTSS | P25774 | 3/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 5/20 | 0.39 |
| ▸ | DAPK1 | P53355 | 5/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.38 |
| ▸ | FAP | Q12884 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1859333 | 1.00 | DPP4 (0.41) | DPP4CTSSCTSLCTSKFFAR1 | |
| SCHEMBL1883133 | 0.89 | PRMT5 (0.42) | DPP4CTSSCTSLCTSK | |
| SCHEMBL1883135 | 0.89 | PRMT5 (0.42) | DPP4CTSSCTSLCTSK | |
| SCHEMBL1863771 | 0.83 | FFAR1 (0.39) | FFAR1CSF1RDAPK1HRH3CYP2C9 | |
| SCHEMBL1863779 | 0.83 | FFAR1 (0.39) | FFAR1CSF1RDAPK1HRH3CYP2C9 | |
| SCHEMBL1808468 | 0.80 | PRMT5 (0.46) | — | |
| SCHEMBL1808466 | 0.80 | PRMT5 (0.46) | — | |
| SCHEMBL1879447 | 0.79 | CSF1R (0.38) | FFAR1CSF1RDAPK1HRH3KCNH2 | |
| SCHEMBL1805031 | 0.77 | PRMT5 (0.44) | — | |
| SCHEMBL1808726 | 0.77 | PRMT5 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493877-A1 | PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011053705-A1 | PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | WO | disclosed |