Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 5/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | DAPK1 | P53355 | 4/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1863779 | 1.00 | FFAR1 (0.39) | FFAR1CSF1RHRH3DAPK1HCRTR1 | |
| SCHEMBL1883592 | 0.89 | PRMT5 (0.41) | ALDH1A1NPC1RAB9A | |
| SCHEMBL1883594 | 0.89 | PRMT5 (0.41) | ALDH1A1NPC1RAB9A | |
| SCHEMBL1859333 | 0.83 | DPP4 (0.41) | FFAR1CSF1RHRH3DAPK1KCNH2 | |
| SCHEMBL1859336 | 0.83 | DPP4 (0.41) | FFAR1CSF1RHRH3DAPK1KCNH2 | |
| SCHEMBL1879447 | 0.77 | CSF1R (0.38) | FFAR1CSF1RHRH3DAPK1DGAT1 | |
| SCHEMBL12660788 | 0.76 | KDM4E (0.41) | CSF1RNPC1RAB9A | |
| SCHEMBL1808725 | 0.75 | PRMT5 (0.44) | ALDH1A1NPC1RAB9A | |
| SCHEMBL1805031 | 0.75 | PRMT5 (0.44) | ALDH1A1NPC1RAB9A | |
| SCHEMBL1808726 | 0.75 | PRMT5 (0.44) | ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493877-A1 | PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011053705-A1 | PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | WO | disclosed |