Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 5/20 | 0.38 |
| ▸ | DAPK1 | P53355 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1880852 | 0.90 | PRMT5 (0.43) | CSF1RDAPK1KCNH2KDM4EPRMT5 | |
| SCHEMBL1880851 | 0.90 | PRMT5 (0.43) | CSF1RDAPK1KCNH2KDM4EPRMT5 | |
| SCHEMBL1866415 | 0.81 | CYP1A2 (0.37) | CSF1RDAPK1KCNH2ALDH1A1SMN1; SMN2 | |
| SCHEMBL1859333 | 0.79 | DPP4 (0.41) | CSF1RDAPK1KCNH2FFAR1HRH3 | |
| SCHEMBL1859336 | 0.79 | DPP4 (0.41) | CSF1RDAPK1KCNH2FFAR1HRH3 | |
| SCHEMBL1863771 | 0.77 | FFAR1 (0.39) | CSF1RDAPK1KCNH2FFAR1HRH3 | |
| SCHEMBL1863779 | 0.77 | FFAR1 (0.39) | CSF1RDAPK1KCNH2FFAR1HRH3 | |
| SCHEMBL12653244 | 0.75 | PRMT5 (0.48) | CPT1AALDH1A1KDM4EMAPTPRMT5 | |
| SCHEMBL1804086 | 0.72 | PRMT5 (0.42) | CSF1RDAPK1ALDH1A1KDM4EPRMT5 | |
| SCHEMBL1298242 | 0.72 | PRMT5 (0.44) | PRMT5SCDSCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493877-A1 | PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011053705-A1 | PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | WO | disclosed |