Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14856433 | 0.91 | CNR2 (0.33) | CNR2TRPV1 | |
| SCHEMBL14856645 | 0.90 | TRPV1 (0.35) | CNR2TRPV1P2RX7POLBMRGPRX4 | |
| SCHEMBL14856668 | 0.88 | CNR2 (0.36) | CNR2TRPV1P2RX7CYP1A2CYP2D6 | |
| SCHEMBL2809088 | 0.87 | CYP1A2 (0.35) | CNR2TRPV1P2RX7CYP1A2CYP2D6 | |
| SCHEMBL14857251 | 0.85 | CNR2 (0.36) | CNR2TRPV1P2RX7CYP1A2CYP2D6 | |
| SCHEMBL14857196 | 0.84 | CNR2 (0.36) | CNR2TRPV1P2RX7CYP1A2CYP2D6 | |
| SCHEMBL14856721 | 0.84 | CNR2 (0.38) | CNR2TRPV1P2RX7CYP1A2CYP2D6 | |
| SCHEMBL14856464 | 0.84 | CNR2 (0.35) | CNR2TRPV1P2RX7CYP1A2CYP2D6 | |
| SCHEMBL14856723 | 0.84 | CNR2 (0.36) | CNR2TRPV1P2RX7CYP1A2CYP2D6 | |
| SCHEMBL204657 | 0.84 | CNR2 (0.37) | CNR2TRPV1P2RX7CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |