Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.83 |
| ▸ | LMNA | P02545 | 1/20 | 0.83 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | TGM2 | P21980 | 1/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8389256 | 0.94 | SMN1; SMN2 (0.74) | SMN1; SMN2LMNAL3MBTL1MAPTHTT | |
| SCHEMBL30823376 | 0.93 | SMN1; SMN2 (0.97) | SMN1; SMN2LMNAL3MBTL1MAPTHTT | |
| SCHEMBL14288938 | 0.92 | LMNA (0.69) | SMN1; SMN2LMNAL3MBTL1MAPTHTT | |
| SCHEMBL5063193 | 0.91 | LMNA (0.77) | SMN1; SMN2LMNAL3MBTL1MAPTHTT | |
| SCHEMBL7372302 | 0.91 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAL3MBTL1MAPTHTT | |
| SCHEMBL7289871 | 0.89 | SMN1; SMN2 (0.78) | SMN1; SMN2LMNAL3MBTL1MAPTHTT | |
| SCHEMBL30229351 | 0.89 | SMN1; SMN2 (0.83) | SMN1; SMN2LMNAL3MBTL1MAPTHTT | |
| SCHEMBL29399108 | 0.89 | SMN1; SMN2 (0.83) | SMN1; SMN2LMNAL3MBTL1MAPTHTT | |
| SCHEMBL15164979 | 0.89 | SMN1; SMN2 (0.83) | SMN1; SMN2LMNAL3MBTL1MAPTHTT | |
| SCHEMBL30723183 | 0.87 | SMN1; SMN2 (0.62) | SMN1; SMN2LMNAL3MBTL1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024073622-A2 | RADIOPHARMACEUTICAL COMPOSITIONS TARGETING EPHRIN TYPE-A RECEPTOR 2 AND USES THEREOF | RAYZEBIO, INC. (US) | 2024-04-04 | — | — | WO | disclosed |
| WO-2023014979-A9 | CONJUGATES COMPRISING COVALENT BINDERS FOR TARGETING INTRACELLULAR KRAS G12C PROTEINS | RAYZEBIO, INC. (US) | 2023-04-27 | — | — | WO | disclosed |
| WO-2023014979-A1 | CONJUGATES COMPRISING COVALENT BINDERS FOR TARGETING INTRACELLULAR KRAS G12C PROTEINS | RAYZEBIO, INC. (US) | 2023-02-09 | — | — | WO | disclosed |
| US-9585975-B2 | MRI contrast agents | NORTHWESTERN UNIVERSITY (US) | 2017-03-07 | — | — | US | disclosed |