Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.34 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23059764 | 0.98 | LMNA (0.43) | LMNATHRBHTTMEN1KMT2A | |
| SCHEMBL19334591 | 0.96 | LMNA (0.48) | LMNATHRBHTTMEN1KMT2A | |
| SCHEMBL19334623 | 0.96 | LMNA (0.48) | LMNATHRBHTTMEN1KMT2A | |
| SCHEMBL19035550 | 0.94 | LMNA (0.46) | LMNATHRBHTTMEN1KMT2A | |
| SCHEMBL15758044 | 0.92 | LMNA (0.45) | LMNATHRBHTTMEN1KMT2A | |
| SCHEMBL9233920 | 0.89 | LMNA (0.48) | LMNATHRBHTTMEN1KMT2A | |
| SCHEMBL23059914 | 0.88 | LMNA (0.45) | LMNATHRBHTTMEN1KMT2A | |
| SCHEMBL15845184 | 0.87 | HTT (0.45) | LMNATHRBHTTMEN1KMT2A | |
| SCHEMBL14958272 | 0.87 | LMNA (0.48) | LMNATHRBHTTMEN1KMT2A | |
| SCHEMBL23060040 | 0.86 | LMNA (0.43) | LMNATHRBHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586931-B2 | Triazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |