Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19334623 | 0.98 | LMNA (0.48) | LMNADNM1CYP3A4OPRM1TSHR | |
| SCHEMBL19334591 | 0.98 | LMNA (0.48) | LMNADNM1CYP3A4OPRM1TSHR | |
| SCHEMBL23059764 | 0.96 | LMNA (0.43) | LMNADNM1CYP3A4OPRM1ALDH1A1 | |
| SCHEMBL18595201 | 0.94 | LMNA (0.45) | LMNADNM1CYP3A4OPRM1TSHR | |
| SCHEMBL15758044 | 0.94 | LMNA (0.45) | LMNADNM1CYP3A4OPRM1TSHR | |
| SCHEMBL9233920 | 0.86 | LMNA (0.48) | LMNADNM1CYP3A4OPRM1ALDH1A1 | |
| SCHEMBL23059914 | 0.85 | LMNA (0.45) | LMNADNM1CYP3A4OPRM1ALDH1A1 | |
| SCHEMBL11989345 | 0.84 | CYP3A4 (0.50) | LMNACYP3A4OPRM1ALDH1A1TDP1 | |
| SCHEMBL14958272 | 0.84 | LMNA (0.48) | LMNADNM1CYP3A4OPRM1TSHR | |
| SCHEMBL30198860 | 0.82 | HTT (0.52) | LMNADNM1CYP3A4ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688669-B2 | Oxazolidinones as modulators of mGluR5 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-06-27 | — | — | US | disclosed |