Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | FDPS | P14324 | 4/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | UBE2N | P61088 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18595200 | 1.00 | LMNA (0.52) | LMNAALDH1A1FDPSCA2DNM1 | |
| SCHEMBL12477442 | 0.81 | LMNA (0.47) | LMNAALDH1A1FDPSCA2DNM1 | |
| SCHEMBL21166547 | 0.80 | LMNA (0.56) | LMNAALDH1A1FDPSCA2CYP2D6 | |
| SCHEMBL21166526 | 0.80 | LMNA (0.56) | LMNAALDH1A1FDPSCA2CYP2D6 | |
| SCHEMBL10457247 | 0.79 | LMNA (0.54) | LMNAALDH1A1FDPSCA2DNM1 | |
| SCHEMBL4024156 | 0.77 | LMNA (0.56) | LMNAALDH1A1FDPSDNM1SPHK1 | |
| SCHEMBL5176712 | 0.76 | LMNA (0.50) | LMNAALDH1A1FDPSCA2DNM1 | |
| SCHEMBL12477841 | 0.76 | LMNA (0.50) | LMNAFDPSCA2CYP2D6SPHK1 | |
| SCHEMBL29286434 | 0.76 | LMNA (0.50) | LMNAFDPSCA2CYP2D6SPHK1 | |
| SCHEMBL25543593 | 0.76 | LMNA (0.45) | LMNAALDH1A1FDPSCA2DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586931-B2 | Triazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |