Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9873342 | 0.85 | PLA2G2C (0.39) | PLA2G2CHSD17B10CYP2C19CYP2C9TSHR | |
| SCHEMBL18609453 | 0.85 | PLA2G2C (0.39) | PLA2G2CHSD17B10CYP2C19CYP2C9TSHR | |
| SCHEMBL24824267 | 0.82 | HTT (0.42) | PLA2G2CHSD17B10CYP2C19CYP2C9TSHR | |
| SCHEMBL21895581 | 0.81 | THRB (0.39) | PLA2G2CHSD17B10CYP2C19CYP2C9TSHR | |
| SCHEMBL11672490 | 0.80 | KDM4E (0.44) | PLA2G2CHSD17B10CYP2C19TSHRHTT | |
| SCHEMBL5907150 | 0.79 | KDM4E (0.48) | HSD17B10CYP2C19TSHRHTTKDM4E | |
| SCHEMBL19880764 | 0.77 | PLA2G2C (0.37) | PLA2G2CHSD17B10CYP2C19CYP2C9TSHR | |
| SCHEMBL1372284 | 0.76 | USP2 (0.41) | PLA2G2CHSD17B10CYP2C19CYP2C9TSHR | |
| SCHEMBL9873857 | 0.76 | HTT (0.38) | PLA2G2CHTT | |
| SCHEMBL16885288 | 0.75 | HTT (0.34) | PLA2G2CHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586931-B2 | Triazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |