Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18595670 | 0.83 | PSIP1 (0.45) | BRD4HPGDKDM4EALDH1A1GAA | |
| SCHEMBL18024067 | 0.82 | CYP17A1 (0.46) | PIK3C3HPGDKDM4EALDH1A1GAA | |
| SCHEMBL24576532 | 0.81 | PIK3C3 (0.48) | PIK3C3PTGS1PTGS2PIK3CAPIK3CG | |
| SCHEMBL17951261 | 0.80 | HPGD (0.45) | BRD4HPGDKDM4EALDH1A1GAA | |
| SCHEMBL17996190 | 0.80 | BRD4 (0.40) | BRD4PIK3C3HPGDKDM4EALDH1A1 | |
| SCHEMBL18160750 | 0.71 | BRD4 (0.51) | BRD4PIK3C3PIK3CA | |
| SCHEMBL7549279 | 0.70 | SMN1; SMN2 (0.52) | BRD4HPGDKDM4EALDH1A1GAA | |
| SCHEMBL22447435 | 0.70 | KIT (0.43) | ALDH1A1GAALMNAPIK3CAPIK3CG | |
| SCHEMBL19303539 | 0.70 | HPGD (0.45) | BRD4HPGDKDM4EALDH1A1GAA | |
| SCHEMBL17052891 | 0.70 | CCR1 (0.38) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586949-B2 | Aza-heteroaryl compounds as PI3K-gamma inhibitors | INCYTE CORPORATION (US) | 2017-03-07 | — | — | US | disclosed |