Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 6/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22447427 | 0.86 | KIT (0.42) | KITITKPIK3CGPIK3CAPIK3CD | |
| SCHEMBL22508613 | 0.84 | KIT (0.40) | KITITKPIK3CGPIK3CAPIK3CD | |
| SCHEMBL22447413 | 0.78 | ALPL (0.39) | KITITKPIK3CAHSD11B1 | |
| SCHEMBL25389991 | 0.73 | PIK3CA (0.46) | KITPIK3CGPIK3CAPIK3CDPIK3CB | |
| SCHEMBL31185557 | 0.73 | PIK3CA (0.46) | KITPIK3CGPIK3CAPIK3CDPIK3CB | |
| SCHEMBL24576532 | 0.73 | PIK3C3 (0.48) | PIK3CGPIK3CAPIK3CDPIK3CBHTT | |
| SCHEMBL12459761 | 0.72 | THRB (0.51) | KITPIK3CABRAFLMNAPKM | |
| SCHEMBL18595669 | 0.70 | BRD4 (0.44) | PIK3CGPIK3CALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL22447465 | 0.69 | SLC22A12 (0.44) | KITITKPIK3CGPIK3CAPIK3CD | |
| SCHEMBL925786 | 0.69 | PIK3CB (0.50) | PIK3CGPIK3CAPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3712143-A1 | QUINAZOLINONE COMPOUND AND APPLICATION THEREOF | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2020-09-23 | — | — | EP | disclosed |