Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | CPN1 | P15169 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SHBG | P04278 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20998420 | 0.93 | CPN1 (0.38) | GNAI3GNAO1GNAI1CPN1CPB2 | |
| SCHEMBL21725498 | 0.93 | CPN1 (0.38) | GNAI3GNAO1GNAI1CPN1CPB2 | |
| SCHEMBL22193261 | 0.93 | CPN1 (0.38) | GNAI3GNAO1GNAI1CPN1CPB2 | |
| SCHEMBL22193247 | 0.93 | CPN1 (0.38) | GNAI3GNAO1GNAI1CPN1CPB2 | |
| SCHEMBL19881822 | 0.93 | CCR2 (0.35) | CCR2GNAI3GNAO1GNAI1SIGMAR1 | |
| SCHEMBL26489011 | 0.92 | CPN1 (0.37) | GNAI3GNAO1GNAI1SIGMAR1CPN1 | |
| SCHEMBL23469399 | 0.89 | CPN1 (0.37) | GNAI3GNAO1GNAI1SIGMAR1SLC6A2 | |
| SCHEMBL24489170 | 0.86 | GNAO1 (0.40) | GNAI3GNAO1GNAI1 | |
| SCHEMBL23709494 | 0.86 | CPN1 (0.40) | GNAI3GNAO1GNAI1SIGMAR1SLC6A2 | |
| SCHEMBL23717658 | 0.86 | GNAO1 (0.40) | GNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586952-B2 | Polycyclic estrogen receptor modulators and uses thereof | GENENTECH, INC. (US) | 2017-03-07 | — | — | US | disclosed |