Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 10/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.33 |
| ▸ | PER2 | O15055 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14900465 | 0.82 | RORC (0.40) | RORCP2RX7PTGER1PTGER4PTGER3 | |
| SCHEMBL14902419 | 0.79 | MME (0.38) | RORCP2RX7MAPTPTGER1PTGER4 | |
| SCHEMBL14900568 | 0.79 | RORC (0.39) | RORCP2RX7CXCR3PTGER1PTGER4 | |
| SCHEMBL16939237 | 0.74 | CHRM3 (0.36) | P2RX7PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL16930525 | 0.72 | USP30 (0.36) | TP53 | |
| SCHEMBL16930524 | 0.72 | USP30 (0.36) | TP53 | |
| SCHEMBL14900588 | 0.70 | RORC (0.39) | RORCCXCR3ROCK2 | |
| SCHEMBL16939238 | 0.70 | MME (0.36) | — | |
| SCHEMBL14902418 | 0.69 | CTSD (0.39) | RORCCXCR3TP53MDM2ROCK2 | |
| SCHEMBL18800980 | 0.68 | RORC (0.39) | RORCCXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773335-B1 | OXALIC ACID AMIDES AS NEPRILYSIN INHIBITORS, PHARMACEUTICAL COMPOSITION THEREOF AND PREPARATION THEREOF | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2017-03-08 | — | — | EP | disclosed |