Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.42 |
| ▸ | PRKCI | P41743 | 4/20 | 0.41 |
| ▸ | BRAF | P15056 | 5/20 | 0.39 |
| ▸ | IKBKB | O14920 | 2/20 | 0.39 |
| ▸ | CHUK | O15111 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL100558 | 0.91 | CDK8 (0.42) | LRRK2NUDT1PRKCIBRAFIKBKB | |
| SCHEMBL29541690 | 0.91 | CDK8 (0.42) | LRRK2NUDT1PRKCIBRAFIKBKB | |
| SCHEMBL29540479 | 0.85 | MAP4K4 (0.46) | LRRK2NUDT1PRKCIBRAFIKBKB | |
| SCHEMBL98811 | 0.85 | MAP4K4 (0.46) | LRRK2NUDT1PRKCIBRAFIKBKB | |
| SCHEMBL29540441 | 0.84 | AURKB (0.56) | LRRK2NUDT1PRKCIBRAFIKBKB | |
| SCHEMBL98273 | 0.84 | AURKB (0.56) | LRRK2NUDT1PRKCIBRAFIKBKB | |
| SCHEMBL99271 | 0.82 | BRD4 (0.46) | LRRK2NUDT1PRKCIIKBKBCHUK | |
| SCHEMBL29540881 | 0.82 | BRD4 (0.46) | LRRK2NUDT1PRKCIIKBKBCHUK | |
| SCHEMBL16692485 | 0.80 | PRKCI (0.48) | LRRK2NUDT1PRKCIIKBKBCHUK | |
| SCHEMBL14494697 | 0.79 | NUDT1 (0.64) | LRRK2NUDT1PRKCIIKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2348023-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2017-03-08 | — | — | EP | disclosed |