Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 7/20 | 0.36 |
| ▸ | GABRD | O14764 | 7/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 7/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.36 |
| ▸ | GABRE | P78334 | 7/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 7/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 7/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 7/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7097948 | 0.81 | MRGPRX4 (0.33) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL12251140 | 0.79 | PDE2A (0.38) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10636834 | 0.78 | HTR2A (0.34) | LMNAPOLBGAAHTTMAPT | |
| SCHEMBL531569 | 0.77 | ALDH1A1 (0.36) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL4961852 | 0.76 | MRGPRX4 (0.47) | SMN1; SMN2MRGPRX4ALDH1A1HTT | |
| SCHEMBL30858773 | 0.76 | MRGPRX4 (0.47) | SMN1; SMN2MRGPRX4ALDH1A1HTT | |
| SCHEMBL30858772 | 0.76 | SLC6A4 (0.43) | SMN1; SMN2MRGPRX4ALDH1A1HTTL3MBTL1 | |
| SCHEMBL29179953 | 0.76 | SLC6A4 (0.43) | SMN1; SMN2MRGPRX4ALDH1A1HTTL3MBTL1 | |
| Nitrogen SCHEMBL28714282 | 0.76 | ALDH1A1 (0.46) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL967220 | 0.75 | ALDH1A1 (0.50) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3838903-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | INCYTE HOLDINGS CORP (US) | 2023-11-22 | — | — | EP | disclosed |
| EP-3466953-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | INCYTE HOLDINGS CORP (US) | 2021-02-03 | — | — | EP | disclosed |
| EP-2343298-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2020-05-06 | — | — | EP | disclosed |
| EP-2348023-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2017-03-08 | — | — | EP | disclosed |
| EP-2343299-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2017-03-08 | — | — | EP | disclosed |