Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18600082 | 0.83 | LMNA (0.50) | MEN1KMT2AGPR119ALDH1A1MAPT | |
| SCHEMBL23368546 | 0.75 | GAA (0.55) | GAAMEN1USP2KMT2AADRA2C | |
| SCHEMBL3211670 | 0.74 | PIM1 (0.60) | GAAMEN1USP2KMT2APIM1 | |
| SCHEMBL3211686 | 0.74 | PIM1 (0.60) | GAAMEN1USP2KMT2APIM1 | |
| SCHEMBL14206408 | 0.74 | PIM1 (0.60) | GAAMEN1USP2KMT2APIM1 | |
| SCHEMBL6311733 | 0.73 | KEAP1 (0.47) | GAAMEN1USP2KMT2AADRA2C | |
| SCHEMBL1271996 | 0.72 | CKS1B (0.55) | GAAMEN1USP2KMT2APIM1 | |
| SCHEMBL9984095 | 0.72 | PIM1 (0.48) | GAAMEN1USP2KMT2AADRA2C | |
| SCHEMBL14207419 | 0.72 | CKS1B (0.52) | GAAMEN1USP2KMT2AKDM4E | |
| SCHEMBL23107339 | 0.72 | MAP4K4 (0.36) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078003-B1 | ANILINOPIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME (US) | 2017-03-08 | — | — | EP | disclosed |