Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16417296 | 0.82 | SMN1; SMN2 (0.46) | KMT2AALDH1A1MEN1GAASMN1; SMN2 | |
| SCHEMBL12660665 | 0.73 | TDP1 (0.42) | KMT2AALDH1A1MEN1GAASMN1; SMN2 | |
| SCHEMBL21975125 | 0.72 | SMN1; SMN2 (0.38) | KMT2AALDH1A1MEN1GAASMN1; SMN2 | |
| SCHEMBL25626251 | 0.71 | — | — | |
| SCHEMBL24312000 | 0.70 | ALDH1A1 (0.34) | KMT2AALDH1A1MEN1GAASMN1; SMN2 | |
| SCHEMBL18602233 | 0.68 | PGR (0.32) | KMT2AALDH1A1MEN1GAAHTT | |
| SCHEMBL12462387 | 0.68 | SMN1; SMN2 (0.34) | KMT2AALDH1A1MEN1GAASMN1; SMN2 | |
| SCHEMBL18602471 | 0.68 | SMN1; SMN2 (0.38) | KMT2AALDH1A1MEN1SMN1; SMN2KDM4E | |
| SCHEMBL11401168 | 0.68 | PTPN1 (0.40) | ALDH1A1GAAKDM4EHPGDTDP1 | |
| SCHEMBL14047148 | 0.66 | CA1 (0.37) | KMT2AMEN1SMN1; SMN2HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2348023-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2017-03-08 | — | — | EP | disclosed |