Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.37 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20081207 | 0.76 | LMNA (0.39) | LMNAMAPK1HTTL3MBTL1MAPT | |
| SCHEMBL16364863 | 0.75 | LMNA (0.45) | LMNAMAPK1HTTL3MBTL1MAPT | |
| SCHEMBL19882238 | 0.74 | LMNA (0.48) | LMNAMAPK1HTTL3MBTL1MAPT | |
| SCHEMBL18600307 | 0.73 | KDM4E (0.40) | L3MBTL1MAPTSMN1; SMN2ALDH1A1ATM | |
| SCHEMBL15628561 | 0.72 | KMT2A (0.49) | LMNAMAPK1HTTL3MBTL1MAPT | |
| SCHEMBL20390782 | 0.72 | LMNA (0.47) | LMNAMAPK1HTTL3MBTL1MAPT | |
| SCHEMBL22782219 | 0.71 | LMNA (0.41) | LMNAMAPK1HTTL3MBTL1MAPT | |
| SCHEMBL19391858 | 0.71 | LMNA (0.41) | LMNAMAPK1HTTL3MBTL1MAPT | |
| SCHEMBL18868807 | 0.69 | LMNA (0.40) | LMNAMAPK1HTTL3MBTL1MAPT | |
| SCHEMBL19986771 | 0.69 | LMNA (0.40) | LMNAMAPK1HTTL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078003-B1 | ANILINOPIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME (US) | 2017-03-08 | — | — | EP | disclosed |