Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18600210 | 0.73 | LMNA (0.40) | KDM4EALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL25620241 | 0.71 | KDM4E (0.50) | KDM4EALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13461367 | 0.69 | CES1 (0.46) | ALDH1A1KMT2AMEN1CES2CES1 | |
| SCHEMBL3658960 | 0.69 | CTBP2 (0.52) | KDM4EALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14667472 | 0.69 | CTBP2 (0.52) | KDM4EALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10177334 | 0.69 | CTBP2 (0.52) | KDM4EALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1149133 | 0.69 | CES1 (0.46) | ALDH1A1KMT2AMEN1L3MBTL1CES2 | |
| SCHEMBL13902884 | 0.69 | KDM4E (0.49) | KDM4EALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL19433078 | 0.69 | KDM4E (0.49) | KDM4EALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11339635 | 0.68 | CES1 (0.50) | ALDH1A1KMT2AMEN1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078003-B1 | ANILINOPIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME (US) | 2017-03-08 | — | — | EP | disclosed |