Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13634536 | 0.85 | RAB9A (0.60) | RAB9ASMN1; SMN2CHEK1KDM4EHDAC3 | |
| SCHEMBL13638811 | 0.81 | RAB9A (0.63) | RAB9ASMN1; SMN2CHEK1KDM4EHDAC3 | |
| SCHEMBL2771222 | 0.77 | RAB9A (0.60) | RAB9ASMN1; SMN2CHEK1KDM4EHDAC3 | |
| SCHEMBL14207028 | 0.74 | CHEK1 (0.59) | RAB9ASMN1; SMN2CHEK1KDM4EHDAC3 | |
| SCHEMBL14328610 | 0.74 | RAB9A (0.54) | RAB9ASMN1; SMN2CHEK1KDM4EHDAC3 | |
| SCHEMBL14207144 | 0.73 | CHEK1 (0.83) | RAB9ASMN1; SMN2CHEK1LMNAMAPT | |
| SCHEMBL14207146 | 0.72 | CHEK1 (0.81) | RAB9ASMN1; SMN2CHEK1LMNAMAPT | |
| SCHEMBL14207142 | 0.72 | CHEK1 (0.81) | RAB9ASMN1; SMN2CHEK1LMNAMAPT | |
| SCHEMBL14328572 | 0.72 | CHEK1 (0.64) | RAB9ASMN1; SMN2CHEK1KDM4EIRAK4 | |
| SCHEMBL14207147 | 0.72 | CHEK1 (0.64) | RAB9ASMN1; SMN2CHEK1KDM4EHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078003-B1 | ANILINOPIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME (US) | 2017-03-08 | — | — | EP | disclosed |