Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 14/20 | 1.00 |
| ▸ | HTR2A | P28223 | 7/20 | 1.00 |
| ▸ | HTR2C | P28335 | 6/20 | 1.00 |
| ▸ | HTR2B | P41595 | 6/20 | 1.00 |
| ▸ | DRD2 | P14416 | 4/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL466805 | 0.99 | SIGMAR1 (1.00) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL9451748 | 0.82 | SIGMAR1 (0.69) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL6836352 | 0.79 | SIGMAR1 (0.65) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL8914201 | 0.75 | KCNH2 (0.59) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL1691460 | 0.75 | SIGMAR1 (0.60) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL3812419 | 0.71 | SIGMAR1 (1.00) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL8913637 | 0.71 | SIGMAR1 (0.55) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL1912706 | 0.70 | HTR2C (0.53) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL18838290 | 0.70 | ACHE (0.54) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL19852225 | 0.69 | HTR2A (1.00) | SIGMAR1HTR2AHTR2CHTR2BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646025-B1 | USE OF SIGMA LIGANDS IN BONE CANCER PAIN | ESTEVE LABOR DR (ES) | 2017-03-15 | — | — | EP | disclosed |