Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 7/20 | 0.49 |
| ▸ | HTR7 | P34969 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MLNR | O43193 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL318698 | 0.92 | P2RX7 (0.51) | P2RX7HTR7LMNAMEN1MLNR | |
| SCHEMBL10248378 | 0.86 | P2RX7 (0.49) | P2RX7HTR7LMNAMEN1MLNR | |
| SCHEMBL318165 | 0.84 | P2RX7 (0.47) | P2RX7HTR7LMNAMEN1MLNR | |
| SCHEMBL320083 | 0.83 | P2RX7 (0.53) | P2RX7HTR7LMNAMEN1MLNR | |
| SCHEMBL319292 | 0.82 | P2RX7 (0.54) | P2RX7HTR7LMNAMEN1MLNR | |
| SCHEMBL16244754 | 0.82 | P2RX7 (0.54) | P2RX7HTR7LMNAMEN1MLNR | |
| SCHEMBL318602 | 0.82 | P2RX7 (0.54) | P2RX7HTR7LMNAMEN1MLNR | |
| SCHEMBL16244973 | 0.80 | HTR7 (0.55) | P2RX7HTR7LMNAMEN1CYP1A2 | |
| SCHEMBL16244928 | 0.79 | HTR7 (0.54) | P2RX7HTR7LMNAMEN1MLNR | |
| SCHEMBL18601833 | 0.79 | P2RX7 (0.52) | P2RX7HTR7LMNAMEN1MLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3138841-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2017-03-08 | — | — | EP | disclosed |