Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 6/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 3/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.30 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12833186 | 0.90 | TRPV4 (0.34) | TRPV4PTGDR2FFAR1MRGPRX4AR | |
| SCHEMBL12302988 | 0.82 | TRPV4 (0.38) | TRPV4PTGDR2MRGPRX4AR | |
| SCHEMBL19062302 | 0.82 | TRPV4 (0.35) | TRPV4PTGDR2MRGPRX4AR | |
| SCHEMBL9918202 | 0.79 | TRPV4 (0.36) | TRPV4PTGDR2MRGPRX4AR | |
| SCHEMBL16691094 | 0.79 | TRPV4 (0.39) | TRPV4PTGDR2MRGPRX4AR | |
| SCHEMBL18896348 | 0.76 | TRPV4 (0.36) | TRPV4PTGDR2AR | |
| SCHEMBL9918833 | 0.73 | TRPV4 (0.34) | TRPV4PTGDR2AR | |
| SCHEMBL12833000 | 0.73 | KDM4E (0.35) | ALOX5APFEN1 | |
| SCHEMBL20855644 | 0.71 | AR (0.43) | TRPV4AR | |
| SCHEMBL20855647 | 0.71 | AR (0.43) | TRPV4AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3838903-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2021-06-23 | — | — | EP | disclosed |
| EP-3466953-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2019-04-10 | — | — | EP | disclosed |
| EP-3184526-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2343299-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2017-03-08 | — | — | EP | disclosed |