Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | ICMT | O60725 | 3/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9918202 | 0.88 | TRPV4 (0.36) | TRPV4ICMTPTGDR2S1PR1HTR2A | |
| SCHEMBL24767631 | 0.86 | AR (0.40) | TRPV4ICMTPDE4APDE4BPDE4C | |
| SCHEMBL16691094 | 0.82 | TRPV4 (0.39) | TRPV4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL12302988 | 0.82 | TRPV4 (0.38) | TRPV4ICMTPTGDR2S1PR1HTR2A | |
| SCHEMBL19062302 | 0.79 | TRPV4 (0.35) | TRPV4PTGDR2AR | |
| SCHEMBL9918833 | 0.79 | TRPV4 (0.34) | TRPV4ICMTPTGDR2HTR2ASLC6A4 | |
| SCHEMBL19592269 | 0.78 | SCN1A (0.34) | TRPV4KCNH2 | |
| SCHEMBL18602196 | 0.76 | TRPV4 (0.35) | TRPV4PTGDR2AR | |
| SCHEMBL19592356 | 0.75 | ALDH1A1 (0.34) | AR | |
| SCHEMBL9918207 | 0.74 | TP53 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9662335-B2 | Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as janus kinase inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2017-05-30 | — | — | US | disclosed |