Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.69 |
| ▸ | CA2 | P00918 | 5/20 | 0.69 |
| ▸ | CA9 | Q16790 | 5/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.66 |
| ▸ | MEN1 | O00255 | 5/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | PLK1 | P53350 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | ALPL | P05186 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALPI | P09923 | 1/20 | 0.57 |
| ▸ | ALPG | P10696 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13454591 | 0.85 | ALDH1A1 (0.65) | ALDH1A1KMT2AMEN1LMNATDP1 | |
| SCHEMBL18606688 | 0.84 | CA1 (0.74) | CA1CA2CA9ALDH1A1LMNA | |
| SCHEMBL13454491 | 0.82 | LMNA (0.60) | ALDH1A1KMT2AMEN1LMNATDP1 | |
| SCHEMBL12904257 | 0.82 | ALDH1A1 (0.74) | ALDH1A1KMT2AMEN1LMNATDP1 | |
| SCHEMBL18606689 | 0.81 | CA1 (0.73) | CA1CA2CA9ALDH1A1KMT2A | |
| SCHEMBL13454744 | 0.81 | LMNA (0.62) | ALDH1A1KMT2AMEN1LMNATDP1 | |
| SCHEMBL13454617 | 0.80 | POLB (0.59) | ALDH1A1KMT2AMEN1LMNATDP1 | |
| SCHEMBL13454742 | 0.80 | MAPT (0.61) | CA1CA2CA9ALDH1A1KMT2A | |
| SCHEMBL13453704 | 0.79 | POLB (0.81) | ALDH1A1KMT2AMEN1LMNAGAA | |
| SCHEMBL13454664 | 0.79 | ALDH1A1 (0.65) | ALDH1A1KMT2AMEN1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170073306-A1 | POTENT INHIBITORS OF HUMAN CARBONIC ANHYDRASE II AND BOVINE CARBONIC ANHYDRASE II AND THEIR MECHANISM OF ACTION | CHOUDHARY MUHAMMAD IQBAL (PK) | 2017-03-16 | — | — | US | claimed |
| US-20170073306-A1 | POTENT INHIBITORS OF HUMAN CARBONIC ANHYDRASE II AND BOVINE CARBONIC ANHYDRASE II AND THEIR MECHANISM OF ACTION | CHOUDHARY MUHAMMAD IQBAL (PK) | 2017-03-16 | — | — | US | disclosed |