Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 7/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.36 |
| ▸ | SMO | Q99835 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185954 | 0.91 | DHODH (0.38) | DHODHNTRK1P2RX7DRD4CNR2 | |
| SCHEMBL185134 | 0.89 | DHODH (0.45) | DHODHKITFLT3 | |
| SCHEMBL185476 | 0.84 | KIT (0.40) | DHODHKITFLT3NTRK1P2RX7 | |
| SCHEMBL2805242 | 0.84 | DHODH (0.38) | DHODHNTRK1P2RX7CNR2 | |
| Cyclopropane SCHEMBL185943 | 0.83 | AURKA (0.39) | DHODHNTRK1P2RX7CNR2 | |
| SCHEMBL13159680 | 0.82 | MAPK10 (0.42) | P2RX7CNR2 | |
| SCHEMBL185674 | 0.79 | P2RX7 (0.42) | P2RX7DRD4CNR2 | |
| SCHEMBL185953 | 0.79 | DHODH (0.39) | DHODHCNR2 | |
| SCHEMBL185656 | 0.79 | DHODH (0.40) | DHODHCNR2 | |
| SCHEMBL2805193 | 0.76 | HDAC3 (0.38) | DHODHNTRK1P2RX7CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |