Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 14/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185312 | 0.89 | TAS2R14 (0.42) | EPHX2 | |
| SCHEMBL185954 | 0.84 | DHODH (0.38) | P2RX7CNR2CNR1DRD4 | |
| SCHEMBL185476 | 0.83 | KIT (0.40) | P2RX7CNR2CNR1DRD4 | |
| SCHEMBL2809680 | 0.82 | AKT2 (0.44) | P2RX7CNR2CNR1EPHX2PPARG | |
| SCHEMBL13159815 | 0.80 | MAPK10 (0.45) | P2RX7CNR2EPHX2 | |
| SCHEMBL19418448 | 0.80 | MAPK10 (0.45) | P2RX7CNR2EPHX2 | |
| SCHEMBL186072 | 0.79 | DHODH (0.40) | P2RX7CNR2DRD4 | |
| SCHEMBL185618 | 0.77 | AKT2 (0.39) | P2RX7CNR2CNR1 | |
| SCHEMBL2807114 | 0.76 | IDO1 (0.43) | P2RX7CNR2CNR1 | |
| Cyclopropane SCHEMBL185943 | 0.75 | AURKA (0.39) | P2RX7CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |