Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.40 |
| ▸ | FAP | Q12884 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1631030 | 0.89 | CHRM2 (0.46) | SMYD3HPGDSMN1; SMN2CHRM2CHRM4 | |
| SCHEMBL1630457 | 0.89 | SMYD3 (0.47) | SMYD3NPC1 | |
| SCHEMBL1632875 | 0.84 | HPGD (0.43) | HPGDSMN1; SMN2CHRM2CHRM4CHRM1 | |
| SCHEMBL21430305 | 0.83 | NPC1 (0.44) | HPGDSMN1; SMN2CHRM2CHRM4CHRM1 | |
| SCHEMBL1631843 | 0.82 | DPP4 (0.58) | SMYD3HPGDSMN1; SMN2CHRM2CHRM4 | |
| SCHEMBL8137653 | 0.82 | DPP4 (0.58) | SMYD3HPGDSMN1; SMN2CHRM2CHRM4 | |
| SCHEMBL30110380 | 0.81 | L3MBTL1 (0.51) | MEN1POLBMAPTKMT2A | |
| SCHEMBL8012012 | 0.80 | HPGD (0.45) | HPGDSMN1; SMN2CHRM2CHRM4CHRM1 | |
| SCHEMBL11892759 | 0.80 | HPGD (0.45) | HPGDSMN1; SMN2CHRM2CHRM4CHRM1 | |
| SCHEMBL11892762 | 0.80 | HPGD (0.45) | HPGDSMN1; SMN2CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939534-B2 | e.g. (2-{[2-(3-fluorophenyl)ethyl]amino}-6-piperidyl(3-pyridyl))-N-(3-pyridylmethyl)carboxamide; smooth muscle myosin or non-muscle myosin modulator; hypotensive agent; asthma, chronic obstructive pulmonary disease, bronchoconstrictive disease, glaucoma, pre-menstrual cramps, erectile dysfunction | CYTOKINETICS, INC. (US) | 2011-05-10 | — | — | US | claimed |