Sugi Predict

Sugi Predict / Compounds / SCHEMBL18609458

SCHEMBL18609458

SCHEMBL18609458

CC(C)(C)OCCC(C)(C)N1CCN(C(=O)OC(C)(C)C)CC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ USP2 O75604 1/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.46
▸ MEN1 O00255 1/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ HPGD P15428 1/20 0.40
▸ EPHX2 P34913 1/20 0.40
▸ POLB P06746 1/20 0.39
▸ CHRM2 P08172 1/20 0.39
▸ CHRM4 P08173 1/20 0.39
▸ CHRM1 P11229 1/20 0.39
▸ CHRM3 P20309 1/20 0.39
▸ RECQL P46063 1/20 0.38
▸ EPHX1 P07099 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ LMNA P02545 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ GPR119 Q8TDV5 1/20 0.38
▸ NR1H2 P55055 1/20 0.38
▸ DDB1 Q16531 1/20 0.38
▸ CRBN Q96SW2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1780574 0.80 USP2 (0.51) USP2SMN1; SMN2MEN1KMT2AHPGD
SCHEMBL1088328 0.80 USP2 (0.51) USP2SMN1; SMN2MEN1KMT2AHPGD
SCHEMBL18609293 0.78 USP2 (0.43) USP2SMN1; SMN2MEN1KMT2AHPGD
SCHEMBL18294 0.77 USP2 (0.69) USP2SMN1; SMN2MEN1KMT2AHPGD
SCHEMBL698803 0.77 USP2 (0.69) USP2SMN1; SMN2MEN1KMT2AHPGD
SCHEMBL1778561 0.76 USP2 (0.58) USP2SMN1; SMN2MEN1KMT2AHPGD
SCHEMBL20099526 0.76 USP2 (0.41) USP2SMN1; SMN2MEN1KMT2AHPGD
SCHEMBL470992 0.75 EPHX2 (0.47) USP2SMN1; SMN2EPHX2CHRM2CHRM4
SCHEMBL18745351 0.75 MEN1 (0.51) USP2SMN1; SMN2MEN1KMT2AHPGD
SCHEMBL19258134 0.75 USP2 (0.53) USP2SMN1; SMN2MEN1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10844076-B2 Derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine NEKTAR THERAPEUTICS (US) 2020-11-24 — — US disclosed
US-20190071454-A1 DERIVATIVES OF 6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZIN-5-AMINE NEKTAR THERAPEUTICS 2019-03-07 — — US disclosed
US-10189859-B2 Derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine NEKTAR THERAPEUTICS (US) 2019-01-29 — — US disclosed
US-20170066782-A1 DERIVATIVES OF 6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZIN-5-AMINE NEKTAR THERAPEUTICS 2017-03-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10844076-B2 Derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine KCNJ2, TRPC5, RYR2 USP2 4243/4885SMN1; SMN2 3458/4885MEN1 1531/4885
US-20190071454-A1 DERIVATIVES OF 6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZIN-5-AMINE KCNJ2, TRPC5, RYR2 USP2 4243/4885SMN1; SMN2 3458/4885MEN1 1531/4885
US-20170066782-A1 DERIVATIVES OF 6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZIN-5-AMINE KCNJ2, TRPC5, RYR2 USP2 4243/4885SMN1; SMN2 3458/4885MEN1 1531/4885
US-10189859-B2 Derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine KCNJ2, TRPC5, RYR2 USP2 4243/4885SMN1; SMN2 3458/4885MEN1 1531/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.