Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 19/20 | 0.51 |
| ▸ | HTR2C | P28335 | 18/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23087742 | 0.75 | PRMT5 (0.48) | HTR2AHTR2C | |
| SCHEMBL15646149 | 0.72 | ALDH1A1 (0.52) | HTR2AHTR2CTDP1 | |
| SCHEMBL23087445 | 0.72 | PDE2A (0.49) | HTR2AHTR2C | |
| SCHEMBL31048522 | 0.71 | FGFR3 (0.53) | TDP1 | |
| SCHEMBL380731 | 0.71 | TDP1 (0.61) | TDP1 | |
| SCHEMBL9933261 | 0.71 | HTR2A (0.54) | HTR2AHTR2C | |
| SCHEMBL4829107 | 0.70 | PRMT5 (0.40) | HTR2ATDP1 | |
| SCHEMBL20102295 | 0.70 | TDP1 (0.43) | TDP1 | |
| SCHEMBL23087863 | 0.69 | HTR2A (0.60) | HTR2AHTR2C | |
| SCHEMBL23087580 | 0.69 | HTR2A (0.43) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3347356-A1 | TRICYCLIC FUSED PYRIDIN-2-ONE DERIVATIVES AND THEIR USE AS BRD4 INHIBITORS | Jubilant Biosys Limited (IN) | 2018-07-18 | — | — | EP | disclosed |
| WO-2017042834-A1 | TRICYCLIC FUSED PYRIDIN-2-ONE DERIVATIVES AND THEIR USE AS BRD4 INHIBITORS | JUBILANT BIOSYS LIMITED (IN) | 2017-03-16 | — | — | WO | disclosed |