Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.50 |
| ▸ | PGR | P06401 | 2/20 | 0.49 |
| ▸ | PLA2G7 | Q13093 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18615552 | 0.94 | AR (0.54) | ARKDRIMPDH2PGRPLA2G7 | |
| SCHEMBL18615546 | 0.91 | AR (0.50) | ARKDRIMPDH2PGRPLA2G7 | |
| SCHEMBL28913547 | 0.91 | AR (0.57) | ARKDRIMPDH2PGRPLA2G7 | |
| SCHEMBL18615960 | 0.89 | IMPDH2 (0.53) | ARKDRIMPDH2PLA2G7NPC1 | |
| SCHEMBL18615355 | 0.86 | IMPDH2 (0.53) | ARKDRIMPDH2PLA2G7NPC1 | |
| SCHEMBL18615698 | 0.86 | IMPDH2 (0.50) | ARKDRIMPDH2PLA2G7NPC1 | |
| SCHEMBL18615371 | 0.82 | KDR (0.56) | ARKDRPLA2G7BRAF | |
| SCHEMBL14684311 | 0.81 | MAPT (0.67) | IMPDH2PLA2G7NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18615537 | 0.81 | KDR (0.55) | KDRPLA2G7BRAFCDK8 | |
| SCHEMBL18615699 | 0.80 | IMPDH2 (0.45) | KDRIMPDH2PLA2G7BRAFSLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10745346-B2 | Agonists of protein tyrosine phosphatase SHP-1 | NATIONAL YANG MING CHIAO TUNG UNIVERSITY (TW) | 2020-08-18 | — | — | US | disclosed |
| US-10745346-B2 | Agonists of protein tyrosine phosphatase SHP-1 | NATIONAL YANG MING CHIAO TUNG UNIVERSITY (TW) | 2020-08-18 | — | — | US | disclosed |
| US-20180237385-A1 | AGONISTS OF PROTEIN TYROSINE PHOSPHATASE SHP-1 | NATIONAL TAIWAN UNIVERSITY (TW) | 2018-08-23 | — | — | US | disclosed |
| EP-3345894-A1 | COMPOUND HAVING PROTEIN TYROSINE PHOSPHATASE SHP-1 AGONIST ACTIVITY | Chen, Kuenfeng (TW) | 2018-07-11 | — | — | EP | disclosed |
| WO-2017036405-A1 | COMPOUND HAVING PROTEIN TYROSINE PHOSPHATASE SHP-1 AGONIST ACTIVITY | 陈昆锋 | 2017-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180237385-A1 | AGONISTS OF PROTEIN TYROSINE PHOSPHATASE SHP-1 | PTPRCAP, PTPN18, PTPN1 | AR 1296/4885KDR 621/4885IMPDH2 3325/4885 |
| US-10745346-B2 | Agonists of protein tyrosine phosphatase SHP-1 | PTPRCAP, PTPN18, PTPN1 | AR 1296/4885KDR 621/4885IMPDH2 3325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.