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SCHEMBL18615552

SCHEMBL18615552

Cc1ccc(NC(=O)Nc2ccc(C)c(Oc3ccc(C#N)c(Cl)c3)c2)cc1Oc1ccc(C#N)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AR P10275 1/20 0.54
▸ MAPT P10636 3/20 0.53
▸ LMNA P02545 3/20 0.53
▸ MEN1 O00255 2/20 0.53
▸ KMT2A Q03164 2/20 0.53
▸ RAB9A P51151 2/20 0.53
▸ KDM4E B2RXH2 1/20 0.53
▸ POLB P06746 1/20 0.53
▸ PKM P14618 1/20 0.53
▸ MAPK1 P28482 1/20 0.53
▸ IL18 Q14116 1/20 0.53
▸ KDR P35968 3/20 0.47
▸ PLA2G7 Q13093 5/20 0.46
▸ IMPDH2 P12268 1/20 0.46
▸ PGR P06401 2/20 0.45
▸ TSHR P16473 1/20 0.45
▸ HTT P42858 1/20 0.45
▸ NLRP3 Q96P20 1/20 0.45
▸ BRAF P15056 1/20 0.43
▸ ALDH1A1 P00352 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18615328 0.94 AR (0.60) ARMAPTLMNARAB9AKDR
SCHEMBL14684311 0.89 MAPT (0.67) MAPTLMNAMEN1KMT2ARAB9A
SCHEMBL18615546 0.86 AR (0.50) ARKDRPLA2G7IMPDH2PGR
SCHEMBL28913547 0.86 AR (0.57) ARLMNAKDRPLA2G7IMPDH2
SCHEMBL18615960 0.84 IMPDH2 (0.53) ARMAPTLMNAMEN1KMT2A
SCHEMBL14677788 0.82 KDR (0.60) KDRBRAFCA1CA2CA9
SCHEMBL18615525 0.81 MAPT (0.67) MAPTLMNAMEN1KMT2ARAB9A
SCHEMBL18615355 0.81 IMPDH2 (0.53) ARMAPTLMNAMEN1KMT2A
SCHEMBL18615698 0.81 IMPDH2 (0.50) ARMAPTLMNAMEN1KMT2A
SCHEMBL18615624 0.80 MAPT (0.57) MAPTLMNAMEN1KMT2ARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108026035-B Compounds having protein tyrosine phosphatase SHP-1 agonist activity 陈昆锋 2021-03-30 — — CN disclosed
US-10745346-B2 Agonists of protein tyrosine phosphatase SHP-1 NATIONAL YANG MING CHIAO TUNG UNIVERSITY (TW) 2020-08-18 — — US disclosed
US-10745346-B2 Agonists of protein tyrosine phosphatase SHP-1 NATIONAL YANG MING CHIAO TUNG UNIVERSITY (TW) 2020-08-18 — — US disclosed
US-20180237385-A1 AGONISTS OF PROTEIN TYROSINE PHOSPHATASE SHP-1 NATIONAL TAIWAN UNIVERSITY (TW) 2018-08-23 — — US disclosed
EP-3345894-A1 COMPOUND HAVING PROTEIN TYROSINE PHOSPHATASE SHP-1 AGONIST ACTIVITY Chen, Kuenfeng (TW) 2018-07-11 — — EP disclosed
WO-2017036405-A1 COMPOUND HAVING PROTEIN TYROSINE PHOSPHATASE SHP-1 AGONIST ACTIVITY 陈昆锋 2017-03-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180237385-A1 AGONISTS OF PROTEIN TYROSINE PHOSPHATASE SHP-1 PTPRCAP, PTPN18, PTPN1 AR 1296/4885MAPT 4678/4885LMNA 4879/4885
US-10745346-B2 Agonists of protein tyrosine phosphatase SHP-1 PTPRCAP, PTPN18, PTPN1 AR 1296/4885MAPT 4678/4885LMNA 4879/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.