Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 9/20 | 0.59 |
| ▸ | MERTK | Q12866 | 9/20 | 0.59 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.47 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18616324 | 0.87 | AXL (0.46) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18615840 | 0.85 | MERTK (0.58) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18616315 | 0.85 | MERTK (0.60) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL21779412 | 0.83 | AXL (0.56) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18616320 | 0.79 | AXL (0.60) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18617176 | 0.78 | MERTK (0.57) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18580983 | 0.76 | AXL (1.00) | AXLMERTK | |
| SCHEMBL21779419 | 0.74 | MERTK (0.61) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL24838113 | 0.74 | MERTK (0.58) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18616319 | 0.74 | MERTK (0.58) | AXLMERTKBMPR1BBMPR1ATGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344613-B1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG A SOCIO HOLDINGS CO LTD (KR) | 2020-03-04 | — | — | EP | disclosed |
| WO-2017039331-A1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG-A SOCIO HOLDINGS CO., LTD. (KR) | 2017-03-09 | — | — | WO | disclosed |