Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 10/20 | 0.56 |
| ▸ | MERTK | Q12866 | 9/20 | 0.56 |
| ▸ | MET | P08581 | 2/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.47 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.47 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18615786 | 0.84 | AXL (0.57) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18616315 | 0.83 | MERTK (0.60) | AXLMERTKMETBMPR1BBMPR1A | |
| SCHEMBL18616305 | 0.83 | AXL (0.59) | AXLMERTKMETBMPR1BBMPR1A | |
| SCHEMBL18617171 | 0.82 | AXL (0.49) | AXLMERTKMETBMPR1BBMPR1A | |
| SCHEMBL18616276 | 0.81 | AXL (0.58) | AXLMERTKPIK3CBLRRK2PIK3C3 | |
| SCHEMBL18616286 | 0.78 | MERTK (0.55) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL16380633 | 0.75 | ALDH1A1 (0.48) | KIT | |
| SCHEMBL18615800 | 0.74 | AXL (0.56) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18615504 | 0.73 | BMPR1B (0.68) | AXLMERTKMETBMPR1BBMPR1A | |
| SCHEMBL29042010 | 0.73 | BMPR1B (0.60) | AXLMERTKBMPR1BBMPR1ATGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344613-B1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG A SOCIO HOLDINGS CO LTD (KR) | 2020-03-04 | — | — | EP | disclosed |